Labile Hemoglobin - A Biochemical Entity
نویسندگان
چکیده
منابع مشابه
Labile hemoglobin A1c: unexpected indicator of preanalytical contraindications.
Labile hemoglobin A 1c (Hb A 1c), or pre–Hb A 1c , is an intermediate in the synthesis of Hb A 1c and is characterized by the reversible binding of glucose to Hb as a Schiff base (1). Its biological variation is related to recent fluctuations in glycemia and cannot provide suitable retrospective information on a patient's long-term glycemic balance. Therefore, labile Hb A 1c must be eliminated ...
متن کاملLabile glycosylated hemoglobin contributes to hemoglobin A1 as measured by liquid chromatography or electrophoresis.
The utility of glycosylated hemoglobin (HbA1) measurement as an index of chronic control in diabetes can be adversely affected by interference from a labile glycosylated fraction that changes rapidly with acute changes in blood glucose concentration. I used a "high-pressure" liquid-chromatographic assay and a newly developed electrophoretic assay to quantitate the contribution of this labile fr...
متن کاملRapid method for eliminating labile glycosylated hemoglobin from the assay for hemoglobin A1.
The irreversible formation of stable glycosylated hemoglobin proceeds through a labile intermediate that is indistinguishable, by most methods, from the stable glycosylated product. The inclusion of the labile intermediate, which changes acutely with acute blood glucose changes, detracts from the utility of the assay as an index of chronic glucose concentration. We have developed a rapid, relia...
متن کاملHemoglobin Yakina. I. Clinical and biochemical studies.
Three members of a family who have erythrocytosis and a new hemoglobin, designated hemoglobin Yakima, are described. The abnormal hemoglobin is characterized by the substitution of histidine for aspartic acid at residue 99 in the beta-chain. Of three possible structure-function relations which would account for the increased oxygen affinity of hemoglobin Yakima, only two seem likely. These are:...
متن کاملNeuromyelitis Optica in Children: A Rare Entity
Neuromyelitis optica (also known as Devic's disease or Devic's syndrome) is an uncommon disorder in pediatric age group, and is characterized by acute or subacute optic neuritis and transverse myelitis. Here we report an 11- year- old female child with relapsing Neuromyelitis optica (NMO) confirmed by positive NMO- IgG antibody and had clinical recovery with high dose methyl prednisolone t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical and Experimental Investigations
سال: 2019
ISSN: 1309-6621
DOI: 10.5799/jcei/6340